What Is GeneSight Testing?
GeneSight is a clinically validated pharmacogenomic test that analyzes genetic variations affecting how your body metabolizes psychiatric medications. The test examines key cytochrome P450 enzymes and pharmacodynamic genes to predict your likely response to over 60 FDA-approved medications used in psychiatry, including antidepressants, anxiolytics, stimulants, mood stabilizers, and antipsychotics.
Results are stratified into three categories: medications predicted to function as expected, medications requiring potential dose modifications, and medications with significant gene-drug interactions that may reduce efficacy or increase adverse effects.
Clinical Value of Pharmacogenomic Testing
Standard psychiatric prescribing involves sequential medication trials -- a process that can take months or years to identify effective treatment. Published research, including the GUIDED trial, demonstrates that pharmacogenomically guided treatment leads to significantly higher remission rates in treatment-resistant depression compared to unguided prescribing.
GeneSight data is most valuable when integrated with clinical assessment. Genetic information does not replace provider judgment; it augments it. A medication flagged as potentially problematic may still be appropriate at adjusted doses, while a medication in the "use as directed" category may not address your specific symptom profile. We interpret results within the full clinical context.
What to Expect
The test requires a buccal (cheek) swab collected during a standard office visit. The sample is sent to the GeneSight laboratory, with results typically available within 3-5 business days. Your provider reviews the report with you and explains how the findings apply to your current or planned medication regimen.
Insurance and Payment
GeneSight is covered by Medicare, most Medicaid plans, and many commercial insurers. For patients with out-of-pocket costs, GeneSight offers a financial assistance program that significantly reduces the price. We verify coverage prior to ordering the test.
When to Consider GeneSight
GeneSight testing is most indicated for patients who have had inadequate response to two or more psychiatric medications, have experienced significant adverse effects, or wish to optimize initial medication selection. If your treatment history involves multiple medication switches without satisfactory results, genetic data can clarify why and guide a more targeted approach.