What is GeneSight Testing?
GeneSight is a pharmacogenomic test that analyzes genetic variants affecting drug metabolism. A cheek swab -- no blood draw required -- provides data on how your body processes over 60 FDA-approved psychiatric medications. Results categorize medications into those likely to work at standard doses, those requiring dose modifications, and those your body metabolizes poorly.
Approximately 40% of patients do not achieve adequate response to their first psychiatric medication. Pharmacogenomic data reduces this trial-and-error period by identifying metabolic factors upfront.
Clinical Indications
GeneSight is most clinically useful for patients with treatment-resistant symptoms or a history of poor medication response -- inefficacy, intolerable side effects, or loss of therapeutic effect over time. It is also indicated when family history suggests atypical drug metabolism patterns.
We apply GeneSight data across diagnoses: depression, anxiety, ADHD, PTSD, bipolar disorder, OCD, and others.
How It Works
The collection takes approximately two minutes. Your provider swabs the buccal mucosa and submits the sample to the GeneSight laboratory. Results are returned in 5-7 business days. Your provider reviews the pharmacogenomic report with you and integrates the findings into your treatment plan.
Insurance and Cost
Most commercial insurance, Medicare, and many Medicaid plans cover GeneSight. Financial assistance programs are available for uninsured and underinsured patients. Typical out-of-pocket cost ranges from $0-$330. We verify coverage before ordering.
Limitations
GeneSight informs medication selection -- it does not make the decision. It does not diagnose psychiatric conditions. Pharmacogenomic data is one input among several: clinical presentation, symptom severity, treatment history, and provider judgment all factor into prescribing. In the Triangle, where many patients are research-oriented, we find that framing it this way resonates -- it is data that improves decision-making, not a replacement for clinical expertise.