What Is GeneSight Testing?
GeneSight is a pharmacogenomic test that analyzes your DNA to help predict how you may respond to certain psychiatric medications. The test looks at genes involved in drug metabolism -- how quickly your body processes different medications. Some people metabolize certain drugs too fast (making them ineffective) or too slowly (increasing side effects). GeneSight identifies these patterns so your provider can make more informed prescribing decisions.
The test covers over 60 FDA-approved medications used to treat depression, anxiety, ADHD, PTSD, bipolar disorder, and other conditions. Results are organized into three categories: medications likely to work as expected, medications that may need dose adjustments, and medications that may cause problems due to your genetic makeup.
How GeneSight Helps
The traditional approach to psychiatric medication is trial and error. You try a medication, wait weeks to see if it works, and if it does not, you try another. For some patients, this cycle repeats three, four, five times before finding the right fit. GeneSight reduces that guesswork. Research shows that patients guided by pharmacogenomic testing are 50% more likely to achieve remission from depression compared to those treated without it.
GeneSight does not replace clinical judgment. It is one more piece of information your provider uses alongside your symptoms, history, and preferences to build the best treatment plan.
What to Expect
The test itself is painless and takes about a minute. We swab the inside of your cheek, send the sample to the GeneSight lab, and results typically come back within a few days. Your provider then reviews the results with you and explains how they apply to your current or future medication plan.
Insurance and Payment
GeneSight is covered by many insurance plans, including Medicare and most commercial insurers. Out-of-pocket costs for those without coverage are often lower than expected -- GeneSight offers a financial assistance program. We can help you check your coverage before ordering the test.
When to Consider GeneSight
GeneSight is most helpful if you have tried two or more psychiatric medications without adequate results, experienced significant side effects from medications, or want to reduce the trial-and-error process from the start. If you feel stuck in a cycle of switching medications, this test can provide a clearer path forward.